Tuesday, June 4, 2019

Development of Controlled Drug Delivery Systems (CDDS)

Development of Controlled Drug Delivery Systems (CDDS)1.1 CONTROLLED DRUG DELIVERY SYSTEMS (CDDS)Now a days on the evolution of Novel dose deliverance systems (NDDS) marked consideration has been focused. The method of medicine spoken language to the site of action shows a signifi dealt effect on its efficacy. It leads to the exploitation and evolution of novel drug sales pitch systems that enhanced per fakeance of potential drug molecules. Novel drug speech systems play a key character in pharmaceutical research and sufferment. Since when comp bed new chemical moiety the instructional comprise and time required for introducing NDDS is relatively low.Oral route remains whizz(a) of the most natural routes of drug administration and has seen remarkable accomplishments in the last couple of decades towards optimization of oral delivery of drug molecules. Oral ingestion is one of the oldest and most extensively used routes of drug administration. They provide an effective me thod of obtaining systemic and local effects.Drug delivery describes a process whereby a remedial agent is administered to the body in a controlled manner. The products commercial and clinical value, product diametricaliation can be improved by substantial drug delivery technologies. These advanced technologies serve as an advanced resource to outreach the competition. By simplifying the administration and dosing regimen drug delivery technologies make medicine more than(prenominal) acceptable and convenient to a patient.Any drug molecule by using Novel drug delivery system (NDDS) can get a new life, and thus improving the competitiveness, patent life and market value. Among different NDDS present in the market, the major shargon in the market is hold by the oral controlled divergence systems because of its greater benefits of patient compliance and ease of administration. The development of novel and highly versatile delivery systems and osmotic drug delivery systems are the major contribution in oral NDDS.Basically, there are three novel modes of drug delivery, i.e.Targeted delivery,Modulated release andControlled release.Targeted delivery refers to the administration of a drug carrier systemically in order to deliver drug to the particular proposition type of cells, tissues or organs. Modulated release implies use of a drug delivery cheat that releases the drug under controlled environmental conditions, bio feedback, sensor input or an external control device at a variable rate. Controlled release refers to a specific device that delivers the drug at specific release profiles or at a predetermined rate into the patient body.1.1 CONTROLLED DRUG DELIVERY SYSTEMS (CDDS)The nature of the controlled release sexually transmitted disease shit is such that the release is determined by the design of the system and the physiochemical properties of the drug and is in numberent of the external factors or the microenvironment in which the dosage form is placed. These products typically provide significant benefits over immediate-release conventional dosage formulations. Optimum therapy with repetitive administration of conventional dosage forms (e.g. injectables, liquids or tablets) can classically be pursued by dosage scheduling. The aim of this process is to maintain drug stringency in a therapeutic range, above the minimum effective ducking and below the toxic closeness. then CDDS avoids the undesirable saw tooth characteristics of the plasma concentration vs time profiles of the conventional drug products.A diagrammatic illustration of controlled versus conventional dosage delivery is shown in Figure-1.Fig 1.1 Plasma Time profile of controlled drug release and conventional releaseThe plasma concentration of the drug reaches a utmost (crest) with conventional dosage forms and then decrease (trough) at the point where repeated administrations becomes necessary to maintain the plasma drug concentration. Very often the initial concen tration is above the therapeutically effective level that may increase the risk of side effects. Conventional dosage forms can thus result in a drug regimen in which the drug concentration oscillates between alternating checks of overdose and inefficiency.The delivery of drug at controlled rate over an extended period of time is represented mathematicallyRate in = Rate out = Ke x Cd x VdWhere Cd is the desired drug level, Vd is the volume of distribution and Ke rate content for drug elimination from the body.Added to this, the high cost of development of new, safe, specific and effective drug molecule is prohibitive and under create nations virtually cannot afford such integrated multi-group cost intensive drug development ventures. Therefore, many pharmaceutical industries and drug research institute oriented their efforts to develop pre-programmed unattended delivery of drug at a rate and for a period to meet and achieve the therapeutic need. These systems are coined as Controll ed drug delivery systemsTable 1.1 Classification of oral controlled release systems depending on mechanism ofRelease 3 (vyas etal,2002)1.1.1. ADVANTAGES OF CONTROLLED RELEASE PRODUCTS 4As controlled release dosage form are slightly expensive than conventional formulations, they cannot be justified unless they offer come clinical or practical advantages given belowReduction in dosing absolute frequencyMore uniform effectReduced fluctuation in steady levelsIncreased safety margin of high potency drugsImproved patient doohickey and complianceReduced in total amount of dose administeredAvoidance of night time dosingReducing of GI irritation and former(a) dose link side effects andReduction in health care cost.1.1.2.DISADVANTAGES OF CONTROLLED RELEASE PRODUCTS 4However, controlled drug delivery systems also have some disadvantages. They include,High costPoor systemic availabilityUnpredictable and often poor invitro-invivo correlationPossibility of dose dumpingDosage adjustments potent ial is reducedFirst twisting clearance potential is increasedIn case of hypersensitivity reactions, toxicity or poisoning drug retrieval is difficultEffect of oral dose depends on Mean Residence Time.To control or change the drug release from a dosage form there will be a subjugate of design options. Most of the per oral controlled release dosage forms comes under the category of osmotic, hyaloplasm or reservoir systems. The polymer matrix contains embedded drug in matrix systems in which the release occurs by partitioning of drug into the release medium and polymer matrix. In case of reservoir systems a rate controlling membrane is touch and coated around the drug core. But, drug release from conventional controlled systems i.e., reservoir and matrix systems is affected by various factors like presence of food, pH and different physiological factors. In case of osmotic systems the drug is delivered based on the principles of osmotic pressure. The drug release from this system d oesnt depend on the pH and various physiological parameters and thus by optimizing the drug and systems properties the release characteristics can be modulated.1.2. OSMOTIC DRUG DELLIVERY SYSTEMS A REVIEW1.2.1. HISTORICAL BACKGROUNDIn 1955 Rose and Nelson utilized the principles of osmotic pressure in drug delivery for the first time. They described two systems one that delivered 0.02 ml/day for 100 eld and another that delivered 0.5 ml/day for 4 days, both for use in Pharmacological research.In the 1970s, Higuchi and Leeper proposed a series of variations of the Rose-Nelson pump5. Theeuwes further modified the Rose-Nelson pump and developed a system. Small osmotic pumps of these forms are sold under the trade name ALZET (Alza Corp., CA). The device has a volume of approximately 170l, and the normal delivery rate is 1l/hr.A major milestone was achieved in 1974 with the description by Theeuwes and Alzas co-workers of a tablet design composed of a compressed tablet-core surrounded b y a semi permeable membrane with a single orifice, so-called Elementary osmotic pump (EOP). This design edition for human use was conveniently processable using standard tabletting and coating procedures and equipment. The first two products indomethacin, Osmosin6 and phenylpropanolamine, Acutrim TM6 were launched in the 1980s.Oral osmotic drug delivery system (OODS) development continued with two new OODS designs, the controlled-porosity osmotic pumps (CPOP) and the push-pull osmotic pumps (PPOP). The first of these was the CPOP, which was designed to decrease the risk of extremely localized drug-induced irritation at the site loaded to the orifice.In the 2000s, a new drug product based on OODS technology was formulated to deliver methylphenidate to children (above the age of 6 years) with attention-deficit hyperactivity disorder (ADHD). These delivery systems were based on a new design, the push-stick osmotic pumps (PSOP), which combined immediate and sustained drug release phas es.The drug release from this system doesnt depend on the pH and various physiological parameters and thus by optimizing the drug and systems properties the release characteristics can be modulated. In the last few years more number of patents are granted on these oral omotic drug delivery systems. These systems has ability to improve therapeutic agents clinical profile and so they are comme il faut one of the most attractive technologies today.Osmotically controlled oral drug delivery system for the controlled delivery of active agents follows osmotic pressure principle. For the controlled drug delivery osmotic devices are most assured strategy based systems. Among the controlled drug delivery systems these are most reliable systems. Osmotic systems could be used in the form of implantable devices or oral drug delivery systems. Osmotic pump tablet (OPT) generally consists of a core including the drug, an osmotic agent, other excipients and semi-permeable membrane coat.1.2.2. THEORY Osmosis can be defined as spontaneous movement of a solvent from a solution of lower solute concentration to a solution of higher solute concentration through an ideal semi permeable membrane, which is permeable only to the solvent and impermeable to solute. The pressure applied to the higher-concentration side to inhibit solvent flow is called osmotic pressure8.Osmotic pressure is a colligative property, which depends on concentration of solute that contributes to osmotic pressure. Solutions of different concentrations having the same solute and solvent system exhibit an osmotic pressure proportional to their concentrations. Thus a constant osmotic pressure, and thereby a constant influx of water can be achieved by an osmotic delivery system that results in a constant null order release rate of drug8.PRINCIPLE OF OSMOSISAn osmotic system releases a therapeutic agent at a predetermined, zero order delivery rate based on the principle of Osmosis, which is movement of a solvent from lower concentration of solute towards higher concentration of solute across a semi-permeable membrane.When osmotic system is administered, from the one or more delivery ports the drug that contain suspension or solutions is pumped out of the core due to the hydrostatic pressure developed by the imbibition of water in to the core osmotically through the semi-permeable membrane. By the water influx through semi-permeable membrane the delivery of drug from this system can be controlled.Osmotic pressure is directly proportional to temperature and concentration and the following equation describes the relation between them = cRTwhereOP = osmotic pressure, = osmotic coefficient,c = molar concentration,R = gas constant,T = Absolute temperature.OSMOTIC PUMPSOsmotic pump is a new delivery device, which delivers drugs or other active agents at a controlled rate by the principle of osmosis. Control resides in the water permeation properties of the formulationsTable 1.2 Examples of some markete d band of Osmotic drug delivery system7DEPARTMENT OF PHARMACEUTICAL TECHNOLOGY, SVCPPAGE 1

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